The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

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The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR

Mitochondrial dysfunction is pervasive in human pathologies such as neurodegeneration, diabetes, cancer, and pathogen infections as well as during normal aging. Cells sense and respond to mitochondrial dysfunction by activating a protective transcriptional program known as the mitochondrial unfolded protein response (UPR(mt)), which includes genes that promote mitochondrial protein homeostasis ...

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ژورنال

عنوان ژورنال: Current Biology

سال: 2016

ISSN: 0960-9822

DOI: 10.1016/j.cub.2016.06.002